Fig. 3
From: A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription
IFN-induced gene expression and STAT complexes in MEFs. a, b Log-fold change (lfc)/lfc plot comparing WT or IRF9−/− BMDM with mouse embryonic fibroblast (MEF). mRNA expression (n = 3) ratios, with a cutoff padj ≤ 0.05 and lfc ≥ 1, (IRF9−/−/WT) in resting (a) or in IFN-β- treated (b) cells is plotted. Genes affected by the loss of IRF9 in both cell types are displayed in blue. c, d GO analysis of the IRF9-dependent genes in untreated (c) and IFN-β-treated (d) cells as defined in a, b. The top seven pathways are listed for IRF9-dependent genes (in blue). e Representative genome browser tracks for transcription factor binding at ISG and control loci (scale 0–60): STAT1 (S1/blue), STAT2 (S2/red), and IRF9 (green). Tracks represent ChIP-seq experiments in untreated and IFN-β-treated MEF
