Fig. 1
From: A practical guide for mutational signature analysis in hematological malignancies
Mutational signature de novo extraction vs. fitting. a, b The Alexandrov et al. NNMF framework6,7. From the 96-mutational classes, NNMF extracted the signatures’ relative (a) and absolute (b) contribution among 30 MMs. c Running deconstructSig including all 30 COSMIC signatures several mutational processes were forced to be extracted (i.e., Signature 4). Furthermore, the new mutational process MM1 was not detected, being not included in the 30 COSMIC signatures. d Conversely, running the same fitting approach based on the mutational signature catalog extracted by NNMF, each signature contribution was better estimated for each patient. Sig. = signature
