Fig. 2
From: A practical guide for mutational signature analysis in hematological malignancies
HRDetect BRCA1/BRCA2 deficiency scores in MM. HRDetect was used to analyze the BRCA1/BRCA2 deficiency scores in MM samples a including only signature 8, b including both signatures 3 and 8, and c including only signature 3. In d, the same analysis was performed in 15 BRCA null and 15 BRCA wt breast cancers18. Scores are ordered from highest to lowest and a classification threshold of 0.7 is used to classify samples as HRD-positive (see Davies et al.18). Below each score, the contribution of the six features that are used by HRDetect is shown. Each contribution is given by the amount of a feature in a sample, log-transformed and standardized according to mean and standard deviation of the features in Davies et al.18 and finally multiplied by the corresponding HRDetect logistic regression coefficient. Thus, a positive contribution indicates a feature value higher than the average of the HRDetect original training set, and feature contributions are directly comparable. Sig. = signature
