Fig. 4 | Nature Communications

Fig. 4

From: A practical guide for mutational signature analysis in hematological malignancies

Fig. 4

Mutational signature landscape of immunoglobulin loci. a The 96-mutational classes of all SNV within IGH/IGK/IGL loci. Canonical AID (c-AID) represented the main mutational process within these regions in all tested hematological malignancies, including U-CLLs as recently described3,10,52. b, c Mutational signature relative (b) and absolute (c) contribution within IGH/IGK/IGL loci for each sample tested by deconstructSig. d The Sanger-sequencing-based IGHV mutational status available for each CLL case. Sig. = signature

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