Fig. 5
From: A practical guide for mutational signature analysis in hematological malignancies
Kataegis in hematological malignancies. a Example of a MM patient with a chromothripsis on chromosome 6 associated with APOBEC-mediated kataegis. The solid and dashed lines reflect the total ploidy and the copy number status of the minor allele, respectively. In these plots, the red arch represents a deletion, the green arch represents a tandem duplication and the blue arch represents an inversion. b Inter-mutational distance of all mutations in chromosome 6, color-coded by mutational class. c Ninety-six-mutational classes of all kataegis events on chromosome 6. d Chromothripsis event on chromosome 19 in a therapy-related AML. e Inter-mutational distance of all mutations across chromosome 19. f Ninety-six-mutational classes of all mutations involved in the chromosome 19 kataegis: APOBEC emerged as the dominant mutational process, despite its activity was not detectable across the genome (Supplementary Software File 3)
