Fig. 6
DMF responders show altered levels of CD4+ T cells subsets compared to non-responders. a, b Percentage and absolute number of naïve cells of CD4+ T cells was analyzed in DMF responders (n = 8) and non-responders (n = 4) at baseline and after six months. c–f Central memory T cells (TCM) was defined as CD45RA−CCR7+ and effector memory T cells (TEM) as CD45RA−CCR7+. Graphs show means and S.D. and all analysis between paired patients are performed with paired t test. g, h Normalized protein expression (NPX) in plasma of IL17A, IL17C, CCL28, CDCP1, SLAM, EN-RAGE, IL12B, IL18R CXCL9 CCL4 and TWEAK were analyzed in responders (n = 29) and non-responders (n = 9) at baseline and 6 months after DMF intervention. *P < 0.05, **P < 0.01, ***P < 0.001. Asterisk in (d) indicate P value adjusted for multiple testing. **adjP < 0.01, ***adjP < 0.0001
