Fig. 5 | Nature Communications

Fig. 5

From: Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

Fig. 5

Acetate treatment protects against RSV infection in the absence of T cells. ad Female Rag1 knockout mice (background C57BL/6) were simultaneously infected with RSV and treated with 200 mM acetate in drinking water. Analyses were performed on day five post infection. a Percentage body weight loss post infection relative to initial weight (day 0) (n = 8). Ctrl = untreated and uninfected mice. b RSV viral load detected in lung tissue by real-time PCR (viral copies/g lung tissue) (n = 8). c Total cell number and d differential cell counts in BALF (c, n = 8; d, n = 5). All data are expressed as mean ± SEM. Data are from two independent. Statistical significance between the groups was determined using Kruskal–Wallis test except in b, in which Mann–Whitney was used. *p < 0.05, **p < 0.01, ***p < 0.001. Data in ad are provided as a Source Data file

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