Fig. 2
From: Mutation bias and GC content shape antimutator invasions
Mutational spectrum effects on the invasion speed of antimutator alleles. Points represent the effective selection coefficient (seff) of the invading antimutator alleles, averaged from 200 independent simulations. Panels correspond to different values of the mutation rate of the resident mutator (a, m = 30; b, m = 100; c, m = 300; d, m = 1000). Within each panel, lines depict different values for the fitness cost of deleterious mutations (from top to bottom, sd equals: 0.064, 0.032, 0.016, 0.008, 0.004, 0.002, 0.001). Mutational spectrum effects refers to the differential propensity of mutators to produce deleterious mutations with different fitness cost. We modelled this effect as a multiplicative factor (κ) that modifies sd in the mutator background, such that when κ < 1 mutators produce milder deleterious mutations than antimutators, when κ = 1 there is no difference between backgrounds, and when κ > 1 mutations are more harmful in mutators. The basal deleterious mutation rate (ud) is set to 2 × 10−4 (other parameters as described in Methods)
