Fig. 3
From: Mutation bias and GC content shape antimutator invasions
Impact of the deleterious and lethal mutation rate on antimutator dynamics. Panels a and b show antimutator fitness under two extreme values of the basal deleterious mutation rate (ud = 0.5 × 10−4 and ud = 8 × 10−4, respectively). Points and colours follow the same convention as in Fig. 2. Panel c shows the change in the antimutator’s effective selection coefficient (seff) for various values of the basal deleterious mutation rate (from top to bottom, ud equals: 1.6 × 10−3, 8 × 10−4, 4 × 10−4, 2 × 10−4, 1 × 10−4, 0.5 × 10−4). Fold change refers to the change in seff from κ = 0.25 to κ = 4. Panels d and e show the effects on antimutator dynamics of spectrum-driven differences in the propensity to produce lethal mutations, under two extreme values of the basal lethal mutation rate (ul = 0.2 × 10−5 and ul = 6.4 × 10−5, respectively). Points and colours as in Fig. 2. Panel f shows the change in seff for various values of the basal lethal mutation rate (from top to bottom, ul equals: 6.4 × 10−5, 3.2 × 10−5, 1.6 × 10−5, 0.8 × 10−5, 0.4 × 10−5, 0.2 × 10−5). Fold change is defined as in c. In all cases, the mutation rate of the resident mutator was fixed to a single value (m = 300). Other parameters as described in Methods
