Fig. 1
From: Integrated analyses of murine breast cancer models reveal critical parallels with human disease
Genomic landscape of MMTV-Neu and MMTV-PyMT tumors. The schematic representation of the project workflow is depicted (a), where mammary tumors from two major mouse models are completely characterized through histological, molecular, genomic, and transcriptomic methods. After data integration and analysis, the tumors were compared to human cancers at both genomic and phenotypic levels. Gene expression patterns from MMTV-Neu and MMTV-PyMT tumors were compared by unsupervised clustering, revealing substantial heterogeneity both between and within models. Tumors clustered largely based on histological subtype and not simply genotype. SQU–squamous, MAC–microacinar, PAP–papillary, and CAC–comedo-adenocarcinoma (n = 15 for MMTV-Neu, n = 25 for MMTV-PyMT) (b). Circos plots from whole-genome sequencing results for MMTV-Neu (c) and MMTV-PyMT (d) tumors revealed differences between the strains for genomic alterations. Plots display from outside in; Chromosomal location (Each chromosome is unique color), SNVs (green), copy number alterations (Amplification–Red and Deletions–Blue), and translocations (black lines). Variation from multiple tumors is shown for single-nucleotide variants (e), copy number variants (f), and translocations (g) (n = 3 for each). All error bars present are standard deviation
