Fig. 3

RIG-I and MDA5-dependent genes. a Schematic of how RLR-dependent genes were determined. b Genes that were determined to be dependent on RIG-I and MDA5 (DKO) are shown by heatmap for the 24h time point. Heatmap is set up the same as in Fig. 2b. c Venn diagram of the number of genes missing from DKO, RIG-I^−/−, and MDA5^−/− sequencing results compared to the WT response. d Pathway analysis (Z-scores) of each RLR-KO DE gene list are shown by heatmap. Red shows pathways that activated while blue shows pathways that are inhibited. Pathways are named on the right. n = 3 (DKO), 4 (LGP2^−/−, MDA5^−/−, RIG-I WT, RIG-I^−/−), or 5 (WT B6) independent infections, RNA preparations, and sequencing results. Source data are provided as a Source Data file