Fig. 5
From: Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages
Correlation of chloroquine IC50 of P. cynomolgi Berok K4 continuous culture with P. vivax clinical isolates. a Flow cytometry dot plots (Ethidium/Hoechst) of chloroquine-treated P. cynomolgi Berok K4 continuous culture gated for schizonts population. b IC50 determination of chloroquine in P. cynomolgi Berok K4 continuous culture using the schizont maturation assay (n = 3) with error bars representing standard deviation (SD). c IC50 determination of chloroquine in P. cynomolgi Berok K4 continuous culture using SYBR green I proliferation assay (n = 3) with error bars representing standard deviation (SD) d IC50 of chloroquine in P. cynomolgi Berok K4 continuous culture and P. vivax clinical isolates using the schizont maturation assay. The median ( + /− IQR) values for the IC50 of P. vivax clinical isolates and of P. cynomolgi Berok K4 continuous culture were similar. The non-parametric data in d was analysed using the Mann–Whitney U-Test with the significance level set at P < 0.05. The histograms and lines on box plots and scatter plots represent medians (P. vivax n = 10, P. cynomolgi n = 4) and the error bars the interquartile range (IQR)
