Fig. 3

Aβ-free or not PrP^Sc inocula similarly affect motor activity and survival of C57Bl/6 J mice. a Survival curves of C57Bl/6 J mice inoculated with 1 × 10⁵ uninfected 1C11, Fk-1C11 or APP^null-Fk-1C11 cells via the intracerebral route (i.c.) infused or not with BX912 by intraperitoneal injection (i.p.) starting at 130 days after infection (5 mg per kg body weight per day; 0.25 µl h⁻¹; n = 10 per group). b Static rod test at 160 days after infection in mice inoculated with Fk-1C11 or APP^null-Fk-1C11 cells and treated or not with BX912 (n = 6–10 depending on the group) and in mice inoculated with uninfected 1C11 cells. c Post-mortem ELISA quantification of proteinase K-resistant PrP^Sc in brains of C57Bl/6 J mice infected with Fk-1C11 or APP^null-Fk-1C11 cells-derived inocula and treated or not with BX912. Values are means ± sem. Data in Fig. 3b were analyzed using the two way ANOVA test with Bonferroni post-test correction. Data in Fig. 3c were analyzed using the two-tail Student t-test. ***denotes p < 0.001 vs. mice inoculated with uninfected 1C11 cells, *p < 0.05 vs. untreated Fk-1C11 injected mice, and **p < 0.01 vs. untreated APP^null-Fk-1C11 injected mice. Source data are provided as a Source Data file