Fig. 2 | Nature Communications

Fig. 2

From: Development of bifunctional organocatalysts and application to asymmetric total synthesis of naucleofficine I and II

Fig. 2

The substrate scope of the Mannich/Acylation/Wittig reaction. Reaction condition: 2a (0.1 mmol), acetaldehyde (0.3 mmol), (S,S)-Cat 1 (0.02 mmol), and Et3N (0.05 mmol), in 0.5 mL DCE and 0.5 mL H2O, then acyl halide 3 (0.15 mmol) and Wittig reagent 4 (0.2 mmol). Isolated yield over three steps. Enantiomeric excess determined by HPLC analysis. a The scope of 3,4-dihydro-β-carboline substrates. b The scope of 3,4-dihydro-isoquinoline substrates

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