Fig. 5
From: Supramolecular trap for catching polyamines in cells as an anti-tumor strategy
In vivo antitumor experiments. a Images of tumors excised from MCF-7 xenograft nude mice treated with PBS (control), free P1, free CP5A, a 1:1 mixture of P1 and CP5A, low-dose P1P5A (L), and high-dose P1P5A (H); b Tumor growth curves of the MCF-7 tumor model in the groups treated with PBS, P1, CP5A, 1:1 P1 + CP5A, P1P5A (L), and P1P5A (H), mean ± SD (n = 10 mice per groups); c normalized tumor weights at 10 days after treatment with PBS, P1, CP5A, 1:1 P1 + CP5A, P1P5A (L), and P1P5A (H), mean ± SD (n = 10 mice per group); d changes in body weight observed for MCF-7 xenograft nude mice after treatment with PBS, P1, CP5A, 1:1 P1 + CP5A, P1P5A (L), and P1P5A (H), mean ± SD (n = 10 mice per group); e survival rates of nude mice bearing MCF-7 tumors treated with PBS and P1P5A (H) (n = 10 mice per group); f H&E, TUNEL, and CD31 analyses of tumor tissue at 10 days after treatment with PBS, P1, CP5A, 1:1 P1 + CP5A, P1P5A (L), and P1P5A (H) (scale bar: 50 μm). Significant differences were assessed in (b) and (c) using the t test. **p < 0.01, ***p < 0.001
