Fig. 4
proYeast8DB—connects protein 3D structures with yeast GEM and enables the SNP mapping analysis based on protein structures. a Overview of proYeast8DB formulation. b CLUMPS analysis to find proteins with significant mutation enrichment45. c Function annotation of residue mutation from YML100W and mapping those mutations onto the protein structure. The ‘C’ means the related residue mutation is located on the conservative zone of proteins based on the function annotation. d Classification of strains based on residue mutations in proteins encoded by YML100W, YAR035W, YJL068C and YMR246W. e Classification of strains based on residue mutations from only one protein encoded by YML100W. The statistical analysis is based on Wilcoxon rank sum test
