Fig. 2

Relationship between effect size and minor allele frequency. The meta-analysis effect size (y axis) and the minor allele frequency (x axis) for 20 significant SNPs. Red circles represent the SNPs at previously unreported loci (n = 14) and blue circles represent the SNPs at previously reported loci (n = 6). Effect sizes are measured as odds ratios, which give the odds of the outcome given exposure to one risk allele compared with those to no risk allele