Fig. 6

A model to generate p-types. a Toy example of a p-type generating model with four regions (A–D). The regions are associated with the leaves of a directed tree (black), edges of the tree are associated with a probability to cross it. Two exemplary axons (orange, blue) spread from region D either crossing an edge (dashed lines) or not (dashed X-marks). Inset: resulting p-types; black regions are innervated; s indicates the source region. b Examples of innervation of brain regions predicted by the full model for L5IT (left column) and of reconstructed axons (right column). Sampled axons along the y-axis, brain regions along the x-axis. A black pixel indicates that an axon is innervating a region. Top row: axons originating from L5 of MOs; bottom row: from MOp. c Pairwise distances (hamming distance) between the profiles of brain region innervation. Blue: the data from reconstructed axons (see a); orange: from 10,000 profiles sampled from the tree-based model; green: from 1000 profiles sampled from a naive model taking only the first-order innervation probabilities into account. Left: for axons originating from MOp; right: from MOs. d Increase in innervation probability against the basic innervation probability as in Fig. 5e