Fig. 1 | Nature Communications

Fig. 1

From: CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis

Fig. 1

CD36 in the development of CRC. a Gene chip data were obtained and compared from 6 GEO datasets and TCGA cohorts. COAD colon adenocarcinoma, READ rectal adenocarcinoma. Results are shown as mean ± SEM, **P < .01, ***P < .001, based on Student’s t-test. b qRT-PCR analysis of mRNA expression in paired CRC tissues. Results are shown as mean ± SEM (n = 35), ***P < .001, based on paired Student’s t-test. c Western blots of CD36 protein in 17 pairs of CRC tissues, GAPDH was loaded as a control. d Immunohistochemistry (IHC) of CD36 in colon tissues with different stages of lesions, Scale bar, 50 μm (20×). e Representative images of CD36 staining on tissue microarray (inserts show ×2.5 magnification), Scale bar, 1 mm. f Kaplan–Meier survival curves of TMA (n = 81) and GSE24551 (n = 160) analysis. Source data are provided as a Source Data file

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