Fig. 5 | Nature Communications

Fig. 5

From: Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections

Fig. 5

Functional profiling of infected patient tissue during streptococcal and polymicrobial NSTIs reveals distinct patterns of gene expression. a Network plot of gene ontology (GO) terms enriched within the genes differentially expressed between human tissue biopsies infected with Streptococcus spp. (red, n = 17) or the polymicrobial community (blue, n = 22) (Benjamini–Hochberg adjusted p-value ≤ 0.05, Wald test). Nodes represent enriched GO terms, grouped into functional clusters. b Average expression level, fold change (upper panel) and inter-individual transcriptional variation (lower panel) of selected genes with significantly higher transcript abundances in human tissue infected by Streptococcus spp. (red) or by a polymicrobial community (blue). Source data are provided in Supplementary Data 5, 7, and 8

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