Fig. 4 | Nature Communications

Fig. 4

From: GIGANTEA recruits the UBP12 and UBP13 deubiquitylases to regulate accumulation of the ZTL photoreceptor complex

Fig. 4

The proposed model for UBP12/UBP13 regulation of ZTL. a In the light, GI interacts with ZTL and acts as a co-chaperone, recruiting HSP90 to facilitate folding and maturation of the ZTL protein. Additionally, GI physically bridges an interaction between ZTL and UBP12 or UBP13. UBP12 or UBP13 stabilize the GI-ZTL protein complex before dusk. In the dark, GI dissociates from ZTL, and ZTL mediates ubiquitylation and degradation of the TOC1 protein. b Loss of UBP12 or UBP13 causes instability of ZTL and GI. Interestingly, the TOC1 protein levels are also reduced by loss of UBP12 or UBP13, mimicking the gi loss-of-function mutant

Back to article page