Fig. 6

WT1 controls memory flexibility. a Wt1∆ mice exhibited a lower rate of fear extinction than their control littermates measured at day 5 of extinction; % freezing at day 5 was normalized to freezing at day 1 (unpaired t test: *p = 0.0196). b Wt1∆ mice showed impaired spontaneous alternation (% alternation) in a Y maze test (unpaired t test: *p = 0.0178). c Wt1∆ mice compared to Control mice performed significant different during the acquisition and reversal phase of the reversal learning task in a Y maze. Data are expressed as % correct arm entry (baited arm). A-day 1 and A-day 2: acquisition sessions 1–2; R-day 1 and R-day 2: reversal sessions 1–2 (two-way ANOVA RM; *p = 0.0348; F_(1,17) = 5.263 for acquisition phase; *p = 0.0120; F_(1,17) = 7.916 for reversal phase). d, Wt1∆ mice exhibited an increase in repetitive behavior as indicated by the number of marbles buried in the marble burying test (unpaired t test: *p = 0.0297). Data are expressed as mean ± s.e.m