Fig. 7
Consequences of WT1∆-mediated impaired memory flexibility. a Proposed mechanism of WT1’s effect on memory regulation. An initial experience such as Task 1 (NOL) activates both pro-memory strengthening and pro-memory weakening pathways. When the memory weakening pathways are inhibited by depletion of WT1, there is prolonged memory for Task 1. Retention of Task 1 memory may or may not interfere with the ability to remember a Task 2 (CFC) based on the availability of effectors (limiting vs in excess). b Schematic representation for short-interval sequential training in mice (top panel). Wt1∆ mice showed increased time spent exploring the new location when first trained in NOL and tested 24 h after training (left panel, unpaired t test: *p = 0.0422. Dashed line indicates 50% preference). In the next day after being tested in NOL mice were trained on CFC and Wt1∆ mice spent significantly less time freezing than Control littermates when tested 24 h after training (right panel, unpaired t test: *p = 0.0161). c Schematic representation for long-interval sequential training (top panel). Wt1∆ mice showed increased time spent exploring the new location when first trained in NOL and tested 24 h after training (left panel, unpaired t test: **p = 0.0036. Dashed line indicates 50% preference). Nine days after being tested in NOL, Wt1∆ mice were trained on CFC and compared with control group, they spent comparable amount of time freezing when tested 24 h after training (right panel, unpaired t test: p = 0.3816). Data are expressed as mean ± s.e.m
