Table 2 Model parameters

τ ₁

Memory-strengthening signaling time constant

0.5 h

Should be faster than memory-weakening; not affected by WT1 knockdown

τ ₂

Memory-weakening signaling time constant

36 h control; 144 h WT1 knockdown

Slower than memory-strengthening, prolonged by WT1 knockdown

K₁, K₂

Steady-state gains

3 control; 7.2 WT1 knockdown

N/A

u

Step input magnitude

0.125 nominal Range 0.025 to 0.15 for parameter variation

Applies to all memory tests, and all animals (control or WT1 knockdown)