Fig. 3 | Nature Communications

Fig. 3

From: Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies

Fig. 3

Conserved epitopes are occluded in native trimeric HA. a GC B cells were gated on the indicated tissues from X31-infected mice (day 20) and used for the binding assay to ΔTM HA and trimeric HA. The percentage of GC B cells in three fractions (ΔTM-specific, trimer-specific, and double-positive) were quantitated and plotted. Each circle represents the result from an individual mouse. The combined data from two independent experiments are shown. b Cross-reactivity was examined from lung GC B cells in the mice inoculated with live X31 virus or inactivated X31 virus. c Cross-reactivity was plotted from each group of mice. Each circle represents the result from an individual mouse. The combined data from three independent experiments are shown. The P-value was determined with a two-tailed Mann–Whitney test. ****P < 0.0001. Source data are provided as a Source Data file

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