Fig. 3
From: Distinct methylation levels of mature microRNAs in gastrointestinal cancers
Increased miRNA methylation levels in pancreatic cancer tissue and serum. a, b Enhancement of miR-17-5p (a) and let-7a-5p (b) methylation in pancreatic cancer tissue (n = 12) relative to paired healthy tissue (n = 12). *p < 0.01 (t test). c, d Fraction of methylated miRNA at a specific position of miR-17-5p (c) and let-7a-5p (d) in serum derived from pancreatic cancer patients (n = 5) and healthy controls (n = 5). Healthy control serum was obtained from liver transplantation donors who were confirmed as having no cancer by endoscopy, computed tomography, and by detection of several tumor markers.*p < 0.01 (t test). e, f Fraction of methylated miRNA at a specific position of miR-17-5p (e) and let-7a-5p (f) in serum derived from pancreatic cancer patients before (n = 21) and after (n = 21) surgery. Healthy control serum was obtained from liver transplantation donors who were confirmed as having no cancer by endoscopy, computed tomography, and by detection of several tumor markers.*p < 0.01 (t test). The box range means from the first quartile to the third quartile. The second quartile means the median of the data. The lower limit of the bar was estimated by “the first quartile − 1.5 × interquartile range”, and the upper limit of the bar was estimated by “the third quartile + 1.5 × interquartile range
