Fig. 3
From: The molecular origin and taxonomy of mucinous ovarian carcinoma
9p13 amplification. a WGS case HOV159 showing complex amplification with the majority of breakpoints rejoining internally to chromosome 9. b WGS case 5950 showing simpler amplification with a mixture of internal and external breakpoint fusions. c Overview of all amplified samples (gains in blue, losses in red) showing minimal region of overlap at 33.785–35.159 Mb and association with 9p loss. d All MOC with 9p13 amplification have TP53 mutation and 16/17 also have have CDKN2A loss/loss of heterozygosity (LOH). HD, homozygous deletion. For TP53: No: no mutation detected, Yes: mutation detected. e RNAseq analysis showing genes significantly differentially expressed between amplified and non-amplified (FDR < 0.05). Blue genes = within 9p amplicon, *genes connected in STRING network related to chromosome condensation
