Fig. 3
From: SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair
SOX11 overexpression induces embryonic transcriptional program. a Heat map from two-color microarray analysis depicts clustering of differentially expressed (FDR < 0.05 and fold change > 1.5) probesets in K14-rtTA;TRE-Sox11 epidermis relative to control K14-rtTA epidermis at P4 after 12 h of Dox induction. Data from two biological replicates of each genotype. b Top ten GO biological processes of the differentially expressed genes in SOX11-induced epidermis. Cell organization and movement related (blue) and epidermal differentiation (red) processes are among the most significantly enriched. c High overlap of SOX11-induced signature genes and embryonic epidermal signature genes. The Venn diagrams show overlapping between E13.5 epidermal signature genes and genes changed by SOX11-induction (genes with log2-fold change > 1.5 in both microarrays). Venn diagram hypergeometric p values and the enrichment level (R) of the overlaps are indicated below each Venn diagram, with statistically significant values highlighted in red. d Percentage of genes altered by SOX11 overexpression overlapping with embryonic signature genes. Source data for panels a, c and d are provided as a Source Data file
