Table 1 Discovery, replication, and combined results for the lead SNP rs7594852 at the 2q13 locus

From: Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

  

rs7594852 effect allele (C) frequency

Number

    

Phenotype

Sample sets

Cases

Controls

Cases

Controls

Beta/ORa (95% CI)

P

I2 (95% CI)

P het

Gestational duration

Combined discovery

 

0.53

 

84,689

0.034 (0.024−0.043)

1.88 × 10−12

0 (0.0−13.4)

0.97

 

MoBa_HARVEST

 

0.54

 

7072

0.049 (0.016−0.082)

3.78 × 10−3

  
 

BiB

 

0.51

 

1354

0.058 (−0.028−0.144)

0.18

  
 

FIN

 

0.58

 

865

0.004 (−0.056−0.065)

0.89

  
 

Combined replication

   

9291

0.041 (0.013−0.068)

3.69 × 10−3

0 (0.0−97.4)

0.41

 

All combined

   

93,980

0.034 (0.025−0.043)

3.96 × 10−14

0 (0.0−99.6)

0.64

Postterm birth

Combined discovery

0.55

0.53

7888

52,807

1.1 (1.06−1.14)

4.64 × 10−8

7.3 (0.0−88.1)

0.37

 

MoBa_HARVEST

0.55

0.54

670

5626

1.05 (0.89−1.24)

0.39

  
 

All combined

  

8558

58,433

1.1 (1.06−1.14)

4.34 × 10−8

0 (0.0−99.7)

0.58

  1. aFor the quantitative trait of quantile transformed gestational duration, the column reports beta estimates. For the dichotomous trait postterm birth, odds ratio (OR) estimates are given; CI, confidence interval; I2, heterogeneity estimate (proportion of variance that is due to between study differences); Phet, P value from the Cochran Q test of between study heterogeneity. Individual study association P values are two-sided and obtained by linear regression (for quantile transformed gestational duration) or logistic regression (for postterm birth). Combined P values are also two-sided and obtained from fixed-effects inverse-variance-weighted meta-analysis
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