Table 2 Associations in 15,588 mother–child pairs between rs7594852 genotype and gestational duration

From: Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

  

Fetal effect (unadjusted for maternal genotype)

Fetal effect (adjusted for maternal genotype)

Maternal effect (unadjusted for fetal genotype)

Maternal effect (adjusted for fetal genotype)

Study

N

Beta (95% CI)

P

Beta (95% CI)

P

Beta (95% CI)

P

Beta (95% CI)

P

MoBa_HARVEST

6362

0.041 (0.001, 0.076)

0.020

0.051 (0.011, 0.092)

0.013

0.0065 (−0.029, 0.041)

0.72

−0.020 (−0.060, 0.021)

0.34

ALSPAC

4305

0.028 (−0.013, 0.07)

0.18

0.021 (−0.027, 0.07)

0.39

0.025 (−0.017, 0.067)

0.24

0.014 (−0.034, 0.063)

0.57

DNBC

1396

−0.016 (−0.09, 0.059)

0.68

−0.009 (−0.094, 0.077)

0.84

−0.018 (−0.090, 0.054)

0.63

−0.014 (−0.097, 0.069)

0.75

BiB

1182

0.09 (−0.002, 0.18)

0.055

0.090 (−0.015, 0.19)

0.09

0.045 (−0.049, 0.14)

0.35

0.00065 (−0.11, 0.11)

0.99

MoBa_2008

854

−0.040 (−0.139, 0.058)

0.42

−0.026 (−0.138, 0.085)

0.64

−0.041 (−0.137, 0.056)

0.41

−0.029 (−0.138, 0.080)

0.61

FIN

833

−0.012 (−0.073, 0.050)

0.57

0.021 (−0.053, 0.094)

0.58

−0.005 (−0.057, 0.066)

0.88

−0.029 (−0.10, 0.045)

0.44

EFSOCH

656

−0.037 (−0.147, 0.073)

0.51

0.028 (−0.098, 0.154)

0.67

−0.114 (−0.221, −0.007)

0.037

−0.128 (−0.251, −0.005)

0.043

All combined

15588

0.022 (0.001, 0.044)

0.042

0.032 (0.007, 0.057)

0.012

0.004 (−0.018, 0.025)

0.73

−0.015 (−0.040, 0.010)

0.24

  1. N indicates number of complete mother–child pairs (i.e. where genotype data were available for both mother and child); Beta is estimated under an additive model with rs7594852-C as the effect allele; CI, confidence interval. Individual study P values are two-sided and obtained by linear regression of quantile transformed gestational duration. Combined P values are also two-sided and obtained from fixed-effects inverse-variance-weighted meta-analysis
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