Fig. 6

Chromosome conformations are extensively heterogeneous. a Normalized distribution P(〈R〉/μ(〈R〉)) (μ(〈R〉) is the mean of 〈R〉) for all the 212 pairs of loci reported in ref. ¹⁹. For almost every pair of loci, the associated P(〈R〉/μ(〈R〉)) has multiple peaks, and is widespread. b Histogram of the coefficient of variations CV for all 212 pairs of loci probed in ref. ¹⁹. The CV values are calculated for each pair of loci, using CV = σ(〈R〉)/μ(〈R〉), where σ(〈R〉) is the standard deviation of 〈R〉. For a large number of loci pairs, CV exceeds 0.5, which is a quantitative measure of the extensive heterogeneity noted in the experiment¹⁹