Fig. 6 | Nature Communications

Fig. 6

From: RuvC uses dynamic probing of the Holliday junction to achieve sequence specificity and efficient resolution

Fig. 6

Cartoon representation of the mechanism of HJ resolution by RuvC. a Holliday junction. Cleaved and non-cleaved DNA strands are shown in purple and blue ladder-like representations, respectively. b Binding of the HJ DNA. The subunits of the dimer are shown as yellow green and pink ovals. The scissile phosphate is marked as a purple circle. Cyan circles show active sites in an inactive configuration. c Flipping of the adenine (red) opposite the scissile base. The active site in the catalytic configuration is shown as a red circle. d The second cut. e Resolution products

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