Fig. 2
Il36rn−/− mice are protected from spontaneous weight gain and metabolic dysfunction. a–e Male Il36rn−/− and wt control mice of the same age were kept on normal chow diet up to 12 months of age (n = 5 per group). Weights (a) and daily food intake per mouse (b) were monitored over time from 2 months of age. c EAT and SAT depots mass was measured at 12 months of age. d, e Intraperitoneal glucose tolerance test (GTT) performed at 9 months of age; glucose measurements over time after glucose bolus-injected i.p. (d) and area under curve (AUC) (e) shown. f, g Intraperitoneal insulin tolerance test (ITT) performed at 9 months of age; glucose measurements over time after insulin bolus-injected i.p. (f) and AUC (g) shown. Data represent means ± SEM. Statistical analysis using two-tailed unpaired student’s t-test, or RM two-way ANOVA with Bonferroni’s correction for multiple comparisons for (a), (d) and (f). ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001. Source data are provided as a Source Data file
