Fig. 5
Methyltransferase activity of the MTBC. a Distribution of the characterised mutations that potentially impair methyltransferase function on a global dataset (n = 4595 samples). b Gene expression differences between SigA recognition motifs differentially methylated by each of the three methyltransferases. Red line marks a 0 fold-change in gene expression (no differences). The expression of each gene was tested in both situations, methylated and non-methylated strains, in independent lineages (when possible). c Different overlapping patterns found between SigA recognition motifs and the methylated motifs. The red adenines in the motif are the methylated ones
