Fig. 8

Model of RASP2 rhoptry docking/priming function in apicomplexan parasites. Upon response to an unknown signal, RASP2 binds to phospholipids (PA/PIP2) (a). This promotes association of the rhoptry with the parasite plasma membrane to initiate the assembly of the docking/priming machinery of the rhoptry (b), which results in membrane fusion, an essential step before the release of the rhoptry contents into the host cell (c)