Fig. 1
From: Pathogen-targeting glycovesicles as a therapy for salmonellosis
Synthesis and characterization of AM vesicles. a Synthetic route of amphiphile (AM). b Scanning electron microscopic (SEM) images of AM vesicles with (left) or without (right) Na2S (100 μM). Scale bars represent 400 nm (left) and 100 nm (right), respectively. Inset: Tyndall effect of AM vesicles with or without Na2S. c Hydrodynamic size distribution from DLS analysis in the absence or presence of Na2S (100 μM). d Cumulative release profiles of AM-CIP in PBS, PBS with Na2S (100 μM), simulated gastric fluid (SGF), or simulated intestinal fluid (SIF). Each is performed in triplicate. e In vitro bactericidal activity of free CIP (CIP), CIP-loaded AM vesicles (AM-CIP), and blank AM vesicles against S. typhimurium bacteria. Each is performed in triplicate. f Fluorescence intensity of Fluo-loaded AM vesicles (containing 10 μM Fluo) incubated with S. typhimurium (ST), C. freudii (CF), or S. paratyphi A (SP) (106 CFU mL−1) for 12 h. Data are means ± SD, representative of three technical repeats. Source data are provided as a Source Data file
