Fig. 6
From: Dynamic changes of muscle insulin sensitivity after metabolic surgery
Reprogramming of gene transcripts by DNA methylation at 52 weeks. Seventy-five percent of genes exhibiting transient differences in expression at baseline show changes in DNA methylation at 52 weeks. Chi-square test p < 10−255. Gene ontology analysis identified the indicated number of genes to be altered in the listed cellular processes (right panel) (a). Examples of changes in DNA methylation in IMMP2L (upper panel) and HMGCS2 genes (lower panel). Both genes are only differentially expressed 2 weeks after the surgery (b). Mean ± SEM, obese humans are shown as red circles/lines at baseline, as gray circles/lines at 2 weeks and as blue circles/lines at 52 weeks after surgery. *p < 0.05 (Gene expression unadjusted p-value 2-tailed paired t test, n = 16, methylation data with Benjamini Hochberg correction)
