Fig. 4
From: An in vitro model maintaining taxon-specific functional activities of the gut microbiome
In vitro–in vivo correlation of microbiome pathway and enzyme responses to metformin. a Pathway analysis using the relative abundance of protein groups that are assigned to the selected KEGG pathways (KEGG pathways corresponding to PLS-DA VIP >1 protein groups). b In vitro–in vivo correlation of the changes in relative protein abundance with pathway assignments in microbiome samples following metformin treatment from HFD-fed mice (data shown as mean ± SEM). c Detailed view of the abundance of multiple enzymes in the glycolysis/gluconeogenesis pathway. Data shown here represent the relative abundance of each enzyme normalized against the total intensity of all enzymes detected in the pathway. Levels of significance are according to two sided, non-parametric t-test: *p < 0.05, **p < 0.01, ***p < 0.001. Box spans interquartile range (25th to 75th percentile), and line within box denotes median. Whiskers represent min to max values. n = 7 biologically independent mice. Underlying data are provided in the Source Data file
