Fig. 5
From: Heme and hemoglobin utilization by Mycobacterium tuberculosis
Structure-based identification of a heme-binding pocket in M. tuberculosis DppA. a Ribbon diagram of DppA overlaid with the volume of the solvent-accessible pocket identified by CASTp. The pocket has a Richards’ solvent-accessible surface area of 333.4 Å2 and solvent-accessible volume ~268.4 Å3. b Superimposition of the 10 perturbed conformations of DppA obtained by applying normal mode analysis using three lowest frequency normal modes. The arrows show the direction of opening of the two N- and C-terminal halves. The crystallographic model of DppAwt is colored in red, while all other states are ramped from light gray (most closed) to black (most open). c Docking model of heme (in yellow sticks) bound to the open conformation of DppA (shown as solvent surface with N- and C-terminal halves color-coded as in a). d Zoom-view of DppA residues making contact with heme
