Fig. 7
From: Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii
Membrane-linked sensory domains. a Side view of crTRP1 tetramer in nanodisc, with two of four pre-S1 elbows colored green, two of four post-TRP elbows colored purple, two of four ARDs colored orange and the rest of the molecule colored cyan. Cryo-EM density is shown as gray mesh; the membrane boundaries are indicated by horizontal lines. b Top view of subunit A’s elbows; residues facing the membrane are shown as sticks. c Side view of the ARD from subunit D; residues in proximity to the intracellular membrane boundary (horizontal line) are shown as sticks. d Cartoon illustrating possible gating mechanism that involves lipids (PIP2 in red and PC in dark blue) and that transmits changes in the membrane environment from the ARD and elbow domains through the TRP helices to the S6 gate
