Fig. 3

p63 genomic targets of and enhancer landscape in myoepithelial cells. a, b Heatmap depicting p63 (a) and TCF7 (b) peaks which are unique in normal breast tissue of control women (C only), and BRCA1 (B1 only), and BRCA2 (B2 only) mutation carriers, and overlap between groups. The color key is the score of ChIP-seq signal over selected genomic region, the signals across different genomic regions have scaled to the same length. c Overlap between p63 peaks and TCF7 peaks in control women, BRCA1 and BRCA2 mutation carriers. d Gene tracks depicting p63 and TCF7 signal at selected genomic loci. The x-axis shows position along the chromosome with gene structures drawn below, whereas y-axis shows genomic occupancy in units of rpm/bp. e Pathway-enrichment analysis of genes associated with p63 or TCF7 peaks in normal, BRCA1, or BRCA2 myoepithelial cells or differentially expressed between the indicated cell types. Color scale corresponds to −log(p-value) of significance of enrichment, calculated by MetaCore enrichment analysis test. f Plot depicting super-enhancers in normal myoepithelial cells from control women. g Predicted protein interaction network of TFs identified as core transcriptional regulatory circuits in myoepithelial cells. Legend indicates the source of data used to determine interactions. TFs that are not part of the network were removed