Fig. 6

Graphical abstract of HDAC11’s role in regulating lymph node metastasis. As cancer cells enter the lymph node (top), HDAC11 increases in expression, leading to decreased expression of several transcripts and increased survival within the lymph node. However, as HDAC11 decreases (bottom), the same transcripts increase in expression, leading to an increased migratory phenotype and allowing exit from the lymph node to distant organs. Thus, pharmacologic inhibition of HDAC11 may decrease cancer cell survival within lymph nodes while also increasing their migratory capabilities