Table 1 Mendelian randomization results of coronary heart disease and myocardial infarction
CpG | Phenotype | Chr | Gene | Number of independent cis-meQTLs | IVW MR test OR | IVW MR test 95% CI | IVW MR test P-value | IVW MR test Bonferroni-corrected P-value | Heterogeneity test P-value | Pleiotropy test P-value |
|---|---|---|---|---|---|---|---|---|---|---|
cg09803321 | CHD /MI | 10 | NT5C2 | 3 | 0.28 | 0.20–0.38 | 3.75E−15 | 5.59E−11 | 0.98 | 0.83 |
cg12555086 | CHD /MI | 10 | LIPA | 4 | 0.42 | 0.32–0.54 | 1.41E−11 | 2.10E−07 | 0.62 | 0.37 |
cg18534077 | CHD | 10 | AS3MT | 8 | 0.14 | 0.08–0.26 | 6.02E−11 | 8.98E−07 | 0.26 | 0.50 |
cg02493740 | CHD | 2 | VAMP5 | 7 | 0.33 | 0.23–0.48 | 1.91E−09 | 2.85E−05 | 0.53 | 0.81 |
cg16306978 | CHD | 2 | APOB | 3 | 2.46 | 1.83–3.30 | 2.09E−09 | 3.12E−05 | 0.73 | 0.48 |
cg00908766 | CHD /MI | 1 | CELSR2 | 5 | 2.18 | 1.66–2.87 | 4.34E−08 | 6.47E−04 | 0.12 | 0.55 |
cg00540400 | CHD /MI | 15 | 3 | 3.00 | 2.03–4.45 | 5.99E−08 | 8.93E−04 | 0.38 | 0.57 | |
cg16513277 | CHD /MI | 17 | SMG6 | 3 | 0.06 | 0.02–0.17 | 1.99E−07 | 2.97E−03 | 0.62 | 0.43 |
cg21433558 | CHD | 17 | CNTNAP1 | 5 | 2.69 | 1.82–3.98 | 6.73E−07 | 1.00E−02 | 0.70 | 0.36 |
cg14037218 | CHD | 1 | ADAMTSL4 | 3 | 0.14 | 0.07–0.31 | 1.20E−06 | 1.79E−02 | 0.81 | 0.53 |
cg24267699 | CHD | 9 | ABO | 4 | 2.89 | 1.88–4.44 | 1.34E−06 | 2.00E−02 | 0.61 | 0.47 |
cg21692620 | MI | 17 | CNTNAP1 | 4 | 0.26 | 0.15–0.45 | 1.41E−06 | 2.10E−02 | 0.57 | 0.57 |
