Fig. 8 | Nature Communications

Fig. 8

From: Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection

Fig. 8

Model of replication stress-induced mitotic death. In p53-competent cells replication stress prevents mitotic entry, while lethal replication stress induces SAC-dependent mitotic arrest in cells lacking p53 function. With lethal replication stress WAPL promotes mitotic arrest which drives a dominant pathway of cell death through cohesion fatigue and BAX/BAK apoptosis. Non-canonical mitotic telomere deprotection contributes to a minority of mitotic lethality

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