Fig. 3
From: Homomeric GluA2(R) AMPA receptors can conduct when desensitized
Estimated weighted mean conductance from NSFA of GluA2(R)/γ-2 activation. a Representative GluA2(Q)/γ-2 responses to 1 ms (gray bar) glutamate application (gray traces) with superimposed average (black trace). NSFA was performed on the activation phase (blue highlight; filled blue circles) and deactivation phase (light blue highlight; open blue circles) of the same records, yielding similar estimates of weighted mean conductance. b Pooled current–variance plots for the activation and deactivation of GluA2(Q)/γ-2 currents (n = 5). Error bars indicate s.e.m. c Representative GluA2(R)/γ-2 response to 1 ms glutamate application (as in a). NSFA was performed on the activation phase (pink highlight; filled pink circles) and deactivation phase (light pink highlight; open pink circles) of the same records. Current–variance relationship is non-parabolic for deactivation but parabolic for activation. d Pooled current–variance plots for the activation and deactivation of GluA2(R)/γ-2 currents (n = 8). Error bars indicate s.e.m.
