Fig. 3
From: Metabolomic adaptations and correlates of survival to immune checkpoint blockade
Kyn/Trp ratio alterations associate with patient overall survival in two independent cohorts. a, b Volcano plots showing associations between fold changes (log2 scale) of different serum metabolites (n = 106) and overall survival in melanoma patients. The effect sizes refer to the regression coefficients in a Cox proportional hazards model and the points represent different metabolites. a 4 weeks after nivolumab treatment versus baseline, b 6 weeks after nivolumab treatment versus baseline. q values were calculated using Benjamini-Hochberg multiple testing corrections. A cutoff at q = 0.05 is shown as a horizontal line. c Table summarizing the hazard ratios (HR) of Kyn/Trp (log2 scale) as a predictor at different time points in relation to melanoma patient overall survival using a Cox proportional hazards model. CI, confidence interval. d Kaplan–Meier plot comparing the overall survival in melanoma patients with >50% increases in Kyn/Trp ratios versus those with decreases. e, Table summarizing the hazard ratios (HR) of Kyn/Trp (log2 scale) as a predictor at different time points in relation to CheckMate 025 RCC patient overall survival using a Cox proportional hazards model. f Kaplan–Meier plot comparing the overall survival in RCC patients with >50% increases in Kyn/Trp ratios versus those with decreases. The p values in d, f were based on log-rank tests
