Fig. 3 | Nature Communications

Fig. 3

From: Characterization of transgenic mouse models targeting neuromodulatory systems reveals organizational principles of the dorsal raphe

Fig. 3

Projections of DR neurons in different transgenic mouse lines. a Left: Schematic of each anatomical region analyzed. Right: Fluorescence images showing eYFP-labeled terminals in different brain regions from DR neurons targeted using SERT-Cre, ePET-Cre, DAT-Cre, and PITX3-Cre mouse lines adjacent to thresholded and binarized versions of the same images (scale bar 0.5 mm). b Bar graph showing the percentage of each target region that is covered by terminals from DR neurons labeled in SERT-Cre and ePET-Cre mouse lines (two-way ANOVA, main effect of region, F(8,90) = 10.97, p < 0.0001; no main effect of genotype or region by genotype interaction, F’s < 3.788, p’s > 0.055; n = 6 sections for each region from n = 2 mice in each group). c Same as in b but experiments were performed in DAT-Cre and PITX3-Cre mice (two-way ANOVA, region by genotype interaction F(8,90) = 2.085, p = 0.0453; n = 6 sections for each region from n = 2 mice in each group). Error bars represent SEM. Data provided as a Source Data file

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