Fig. 2
From: Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele
rs6897932 specifically regulates monocyte cell surface IL7R levels. a Microarray data demonstrating eQTL to IL7R noted at rs931555 after both 2 and 24 h treatment with LPS (2 h LPS: n = 261, 24 h LPS n = 322). b Local association plot for monocyte IL7R after exposure to LPS from positively selected monocytes demonstrates peak association to rs6897932 (n = 84). c Batch corrected log values for surface IL7R from positively selected monocytes demonstrating significant effect of rs6897932 carriage after stimulation in comparison to baseline monocytes (n = 84, ANOVA for linear model). d Surface IL7R in PBMCs across cell subsets after exposure to LPS. (n = 87, Note a significant effect of rs6897932 on surface IL7R is only observed in CD14+ monocytes, ANOVA for linear model). e As per d but PBMCs treated with TNF for 24 h (n = 62). Error bars show mean, IQR, min, and max. Source data are provided as a Source Data file
