Fig. 2
Example images considered in our pilot study encompass diverse fields in biomedicine. a Bone-fracture repair involves skeletal stem cells. The images in this example are from mice that were the progeny of a cross between mice carrying Mx1/Tomato (red), which is a skeletal stem/progenitor cells marker, and mice carrying αSMA-GFP or Nestin-GFP (green), which are mesenchymal cell markers. The bones were injured and images were taken in vivo at 7 days and 14 days after injury, when critical events in the early repair process occur. b Chromatin organization (Hoechst staining) in the nucleus of mouse fully grown antral oocytes. Depending on their chromatin organization, oocytes are classified as surrounded nucleolus (SN), with a ring of heterochromatin surrounding the nucleolus and not surrounded nucleolus (NSN) oocytes, with a more dispersed chromatin not surrounding the nucleolus. SN oocytes are developmentally competent, whereas NSN oocytes are incompetent18. c Protein localization in budding yeast—fluorescence micrographs of GFP-fusion proteins localized to the cytoplasm, endosome or endoplasmic reticulum (er) as indicated. d Images of Dictyostelium discoideum cells at different developmental stages—streaming (STR), loose aggregate (LAG), and tight aggregates (TAG). Scale bars are 100 μm (a), 10 µm (b), 5 µm (c), or 1 mm (d). See Supplementary Note 1 for detailed description of the image sets
