Fig. 6
From: Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes
Podocyte-specific loss of PP2A worsens DKD. a Schematics of the experimental design. Doxycycline (Dox) was administered in 6-week old wildtype (WT) or Pod-PP2A−/− mice. Diabetes was induced with STZ at 6 weeks post Dox induction. All mice were killed 8 weeks after diabetes induction, n = 6 mice per group. b Analysis of urinary albumin-to-creatinine ratio (UACR). ***P < 0.001 and ****P < 0.0001 when compared with WT diabetic mice; n = 6. c Representative PAS images. Scale bar, 20 μm. d Quantification of the glomerular area and mesangial matrix fraction in diabetic and control mice, n = 6. ****P < 0.0001 vs. respective nondiabetic mice; ####P < 0.0001 vs. WT diabetic mice by two-way ANOVA with Tukey’s post hoc analysis. The data are represented as mean ± SD. Source data are provided as a Source Data file
